Mechanosensitivity in the enteric nervous system

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Mechanosensitivity in the enteric nervous system

The enteric nervous system (ENS) autonomously controls gut muscle activity. Mechanosensitive enteric neurons (MEN) initiate reflex activity by responding to mechanical deformation of the gastrointestinal wall. MEN throughout the gut primarily respond to compression or stretch rather than to shear force. Some MEN are multimodal as they respond to compression and stretch. Depending on the region ...

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The enteric nervous system.

T HE enteric nervous system is a collection of neu-rons in the gastrointestinal tract 1 that constitutes the " brain of the gut " and can function independently of the central nervous system. 2 This system controls the motility, 3,4 exocrine and endocrine secretions, 5 and microcirculation 6 of the gastrointestinal tract; it is also involved in regulating immune and inflammatory processes. 7 In...

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The human enteric nervous system.

Decades of work in animal models have demonstrated that the enteric nervous system (ENS) plays a key role in controlling gut functions. Recent advances made it possible to extend such studies to the ENS of man in health and even in disease. Such studies have already provided new insights into the pathophysiology of inflammatory and possibly functional bowel diseases. Studies on human ENS reveal...

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Gaseous Mediators in the Enteric Nervous System

The enteric nervous system is an independent nervous system that controls vital gut functions including motility and secretion. Enteric neurons use a variety of neurotransmitters to modulate neural as well as muscle and epithelial activity. Among them are three gaseous mediators which are nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S). All three have potent inhibitory effec...

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GABA in the Mammalian Enteric Nervous System.

gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.

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ژورنال

عنوان ژورنال: Frontiers in Cellular Neuroscience

سال: 2015

ISSN: 1662-5102

DOI: 10.3389/fncel.2015.00408